Applications Iodolactonization

in 2006, zhou , coworkers synthesized natural product, vibralactone, in key step formation of lactone. stereoselectivity of iodolactonization important if desired vibralactone configuration obtained.

in 1969, corey , coworkers synthesized prostaglandin e2 (seen below) using iodolactone intermediate. again, stereoselectivity of iodolactonization plays integral role in product formation.

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